Ashwagandha: side effects
Ashwagandha (Withania somnifera) is generally well tolerated at usual doses, but adverse effects and at‑risk situations exist. Several agencies have issued recent cautionary notes.
Most frequent adverse effects
- GI: nausea, abdominal discomfort, diarrhea/constipation
- Somnolence in some people (notably with evening intake)
- Allergies (rare): rash, itching; stop and seek advice if symptoms appear
Tolerance
Start with a moderate dose, take with food if you have a sensitive stomach, and split into two doses if needed.
Situations requiring particular caution
- Liver: reported cases of liver injury; be cautious with hepatic history; stop and consult if unusual fatigue, dark urine, or jaundice occur
- Pregnancy/breastfeeding: not recommended due to limited data
- Thyroid disease: possible thyroid‑hormone changes; monitor with your clinician
- Sedatives/psychotropics: potential added somnolence; seek medical advice
Regulatory alert
The ANSES has issued a warning on ashwagandha citing adverse effects (including hepatic). Avoid if you have liver disease or are on multiple medications without medical advice.
Interactions and practical advice
- Avoid combining with sedatives (drowsiness)
- With chronic treatments, obtain professional advice (interaction risk)
- Reassess benefit/risk periodically (e.g., at 6–8 weeks) and adjust
